Glucosamine

Acute inflammation, when uncontrolled, can lead to chronic inflammation. Chronic inflammation

can weaken collagen and the connective tissue around the joints. Fortunately, nutritional supplementation can support the normal rebuilding and regeneration of healthy cartilage.

Glucosamine, an amino-monosaccharide produced naturally by the body, is a key component of cartilage. Glucosamine promotes healthy joint function and helps stimulate the production of synovial fluid, which lubricates the joints and assists in the regeneration of cartilage. Numerous studies show that it can help maintain joint flexibility, renew joint fluids and even help regenerate healthy cartilage in the joints and collagen in the bones.*

When considering glucosamine supplementation, supporting ingredients are a key consideration. Vitamin C assists in the cross-linking and strengthening of collagen. Manganese assists in the manufacture of mucopolysaccharides, one of the main components of connective tissue, and has been shown to help maintain healthy cartilage.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References

• Reginster JY, et al. Glucosamine sulfate significantly reduces progression of knee osteoarthritis over 3 years: A large, randomized, placebo-controlled, double-blind, prospective trial. American College of Rheumatology Annual Meeting, Boston MA, 1999.
• Zerkak D, et al. The use of glucosamine therapy in osteoarthritis. Curr Rheumatol Rep 6:41-5, 2004.
• Matheson AJ, et al. Glucosamine: a review of its use in the management of osteoarthritis. Drugs Aging: 20:1041-60, 2003.
• Holick M, et al. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease and osteoporosis. Am J Clin Nutr 79: 362-71, 2004.
• Van Etten E, et al. 1,25-dihydroxycholecalciferol: endocrinology meets the immune system. Proc Nutrition Society 61:375-80, 2002.
• Bowman BA and Russell RM. Present Knowledge in Nutrition, International Life Sciences Institute, 2001.
• Hawk C. Manganese Deficiency and its Role in Structural Balance. The American Chiropractor, March/April, 1982.
• Giner-Larza EM, et al. Oleanolic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity. Eur J Pharmacol 428: 137-43, 2001.
• Ricciardelli C, et al. Elevated stromal chondroitin sulfate glycosaminoglycan predicts progression in early-stage prostate cancer. Clin Cancer Res 3:983-92, 1997.